A Dog Parasite Could Help Fight Incurable Cancers – What Our Immunotherapy Research Revealed

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misbahulalam
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A Dog Parasite Could Help Fight Incurable Cancers – What Our Immunotherapy Research Revealed

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Cancers are the second leading cause of death in the world, after cardiovascular diseases. Their seriousness lies in their diversity – some can be effectively treated with surgery, chemotherapy and radiotherapy, while others respond poorly or not at all. Improving the treatment of these diseases is therefore a major challenge. For several years, the development of immunotherapies – treatments that use various components of the immune system to fight tumors – has offered hope. Some use modified viruses, but these can cause adverse effects for patients. To overcome this problem, our team studied the possibility of instead using the microorganism Neosporin caninum. Harmless to humans, this parasite is found in dogs.

The first results of our research, obtained in mice, are encouraging. First immunotherapies: a positive impact Chemotherapy and radiotherapy prevent the multiplication of tumor cells but also attack non-cancerous cells, and so have serious side effects. In contrast, immunotherapy stimulates the patient’s immune system to Phone Number List target cancerous cells. Different strategies are employed, from the use of antibodies that target cancer cells or that prevent them from inactivating the immune system (known as immune checkpoint inhibitors), to the use of live micro-organisms that induce a strong immune response to destroy tumor cells. Immunotherapeutic approaches have been used since 2001 to treat melanoma: the development of the first immune checkpoint inhibiting antibody has resulted in more than 53.6% of treated patients surviving two years. In 2015, another advance in the management of melanoma resulted in shrinking tumors and increasing survival rates.

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It is based on the use of a herpes virus modified to multiply in tumor cells and cause their death. Immunotherapies could be the key to treating cancers that are currently incurable. Examples include glioblastoma, a serious brain cancer with an average survival of 15 months after diagnosis, and pancreatic cancer, which has an average survival of 8 months. A micro-organism as a new therapeutic hope? N. caninum is a single-celled parasite that can cause severe neurological disease and fontal death in some animals (cattle and canines). However, it’s completely harmless to humans and most rodents, probably due to differences in immune responses. At the same time, N. caninum is able to multiply in vitro in cells of human or mouse origin.
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